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Manchester United could be without the services of Fred and Edinson Cavani for the Premier League clash at Leicester City.
The Red Devils had a disappointing run of games before the international break. They won just one of their last four matches.
The club return to action against the Foxes on October 16, but they could be without Fred and Cavani due to international commitments.
Fred and Cavani are currently on duty with Brazil and Uruguay respectively. Their last game begins at 1.30 am (BST) on October 15.
With a turnaround time of just 36 hours, they are expected to miss the Foxes game with the travel and resting period involved.
The Red Devils have plenty of options to fill the void. Nemanja Matic or Paul Pogba may partner Scott McTominay in midfield.
Cavani has been a regular substitute this term with Cristiano Ronaldo being the undisputed striker to lead the line for Ole Gunnar Solskjaer.
The Portuguese will be expected to start up front after surprisingly started from the bench against Everton before the international break.